DNA-binding protein, spatial regulator of [SW|cell division] to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and [SW|cell division], Z ring placement
function
control of [SW|cell division]
product
effector of nucleoid occlusion
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
4,207,897 → 4,208,748
Phenotypes of a mutant
a ''[gene|1986DB3078FBA16D6ACCD70EEAC95C46564D0958|whiA] [gene|559DEDC9887B811EF80994526256ADC48BA51CE3|noc]'' double mutant grows poorly, and the cells are filamentous [Pubmed|24097947]The protein
Catalyzed reaction/ biological activity
binds specific sites on the chromosome [Pubmed|19494834]Protein family
ParB family (according to Swiss-Prot)Paralogous protein(s)
[protein|EF4BD49FCD49EE97908973581478951C8FA196C0|ParB] Structure
[PDB|1VZ0] ([protein|EF4BD49FCD49EE97908973581478951C8FA196C0|ParB] from Thermus thermophilus, 48% from aa 30 ... 219)[SW|Localization]
associated to the cell membrane [Pubmed|25568309]Expression and Regulation
Operons
genes
[gene|66A6EC4F6CB91EE741BB9D7646913FF3EE602BD7|thdF]-[gene|7809B4F5B9172EBB6C91BDE7B673FB08E82763FF|gidA]-[gene|CCB7EE1D049585979303148FBDE0D42549E648DE|gidB]-[gene|559DEDC9887B811EF80994526256ADC48BA51CE3|noc]
description
[Pubmed|11807071]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK]: activation, [Pubmed|11948146], in [regulon|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK regulon][protein|6740108089F13116F200C15F35C2E7561E990FEB|DnaA]: repression, [Pubmed|26020636], in [regulon|6740108089F13116F200C15F35C2E7561E990FEB|DnaA regulon]regulation
constitutively expressed [Pubmed|23701187]view in new tabBiological materials
Mutant
MGNA-B874 (yyaA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1873 NBRP B. subtilis, Japan]BKE40990 (Δ[gene|559DEDC9887B811EF80994526256ADC48BA51CE3|noc]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE40990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACCTACACCACCTTT, downstream forward: _UP4_TAGAAGCTCTCCTGAAAAGCBKK40990 (Δ[gene|559DEDC9887B811EF80994526256ADC48BA51CE3|noc]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK40990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACCTACACCACCTTT, downstream forward: _UP4_TAGAAGCTCTCCTGAAAAGCGFP fusion
available in the [SW|Jeff Errington] labLabs working on this gene/protein
Jeff Errington, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington Homepage]David Rudner, Harvard, USA [http://rudnerlab.med.harvard.edu/ Homepage]References
Reviews
19680248,19884039,25460802,26706151,28500529 Original Publications
16549676,11807071,19494834,15210112,11948146,22457634,23701187,24097947,25568309,26020636,28723932